Case studies
CHO-K1 Titer Comparison
A CHO-K1 cell line was grown in fed-batch shake flask culture in OPM SagiCHO™ Basal Medium with OPM Feeds (AltairCHO™ Feed / AF169 / AF183 + CDFS36) according to our recommendations, as well as in other basal media and feeds following their manufacturers' recommendations.
Day 14 results demonstrate that higher antibody titers were achieved using OPM SagiCHO™ Medium + OPM Feeds.
CHOZN-GS Titer Comparison
A CHOZN-GS cell line was grown in fed-batch shake flask culture in different media + feeds.
Day 14 results demonstrate that:
- OPM StarCHO™ Feed in combination with OPM basal media promoted the highest titers compared to the benchmark competitor basal medium + feed
- OPM basal media (StarCHO™ Medium and AM266 Medium) promoted higher titers than the benchmark competitor basal medium, no matter with OPM StarCHO™ Feed or Benchmark Feed
StarCHO™ designed for CHO-ZN clones
Compared with the control, StarCHO™ increases 130% antibody titer with comparable antibody quality.
(A) Comparable VCD and VIA of all the test groups.
(B) 130% titer increased using StarCHO system with comparable antibody quality.
Fast Cell Growth and Productivity with SagiCHO™
Compared with the control, SagiCHOTM offers higher viability and increases 130% antibody titer with comparable antibody quality.
(A) The viability SagiCHOTM cultured on the 14th day is 71%, significantly better than that of Control (48%).
(B) 130% titer increased using SagiCHOTM system with comparable antibody quality.
VegaCHOTM media and feeds
VegaCHOTM medium and feed provided > 87% titer increase compared to two major global competitors with comparable antibody quality.
(A) Comparable VCD and VIA of all the test groups.
(B) 87% titer increased using VegaCHO with comparable antibody quality.
