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Stable Cell Line Development

Targeting a wide range of macro molecular drugs (mono-, bi-, tri-antibodies, fusion proteins, enzymes, vaccines, etc.)

Stable Cell Line Development

Efficient stable cell line development is a key step to obtain high-quality protein, as well as for the CMC development. OPM provides comprehensive and professional stable cell line development service to support IND application.

Host cells

  • Wild type: ATCC CHO-Kl, ECACC CHO-Kl, CHOZN CHOK1, CHO-S, etc.
  • Knockout type: CHOZN GS, DG44, etc.
  • GS screening system, DHFR screening system and novel screening system.
  • Host cell systems supplied by clients.

Biologics development

  • Completed 100+ cell line development projects for therapeutic protein expression.
  • Including monoclonal antibodies, bispecific antibodies, tri-specific antibodies, fusion proteins, vaccines, enzymes, cytokines and novel structure proteins.

Fast, high-titer and high-quality development

  • Protein samples delivered within 5 weeks with desired CQAs such as protein quality and titer.
  • Delivery of monoclonal cells in less than 8 weeks.
  • mAb titer: 3-10 g/ L, bispecific antibody titer: 2-10 g/ L, vaccine titer: 1-10 g/ L.

Professional and compliant development process

  • Provide host cells of documented origins.
    Data management: Integrity, authenticity and traceability.
  • Provide clonality report to speed up the application process.
  • 20+ IND applications accomplished in China, US and Australia.

Workflow

Cell Line Development_Workflow