Commercial Media Solutions|OPM Biosciences – Cell Culture Media and End-to-End CDMO

OPM-CHO Platform

Chemically defined basal medium, feeds and supplements

Chinese hamster ovary (CHO) cells are the most common expression platform for commercial-scale production of therapeutic antibodies and recombinant proteins. Based on rational design of formulations and extensive cell culture experience, OPM has developed a series of high-performance basal media, feeds and supplements for different CHO cell lines (e.g. CHO-K1, CHO-DG44, CHO-S, CHOZN etc.). Our chemically defined (CD) cell culture media support cell growth in high-density suspension culture and maximize the expression of antibodies and recombinant proteins.

Product characteristics:

Manufactured under full GMP guidance
Chemically defined with TSE/BSE certificates
Widely used in CHO-K1, CHO-DG44, CHO-S, CHOZN culture by first-class pharmaceutical companies
Up to 130% titer increase in mAb manufacturing compared to the major global competitors
Proven performance in high-density suspension culture
Consistent quality in cell performance assay (intra-lot & inter-lot RSD＜5%)
Flexible packaging size of powder and liquid media at choice
Safe and immediate supply with dual manufacturing facilities of up to 2000kg/lot dry powder and 2000L/lot liquid capacity
Thoughtful technical support

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Product Information

CHO Cell Culture
CHO Transient Transfection

Name	Cat No.	Form	Volume	Type	Cell line	SDS	Description
AltairCHO^® DPM	C670226	Dry powder	10L/50L/100L	Chemically Defined Medium	CHO-K1、CHO-DG44、CHO-S
AltairCHO^® Medium	C673017	Liquid	1000mL	Chemically Defined Medium	CHO-K1、CHO-DG44、CHO-S
AltairCHO^® Feed DPM	C679332	Dry powder	10L	Chemically Defined High Performance Feed	CHO-K1、CHO-DG44、CHO-S
AltairCHO^® Feed	C675219	Liquid	500mL	Chemically Defined High Performance Feed	CHO-K1、CHO-DG44、CHO-S
AltairCHO^® Feed Plus DPM NEW	P225808	Dry powder	10L/50L	Chemically Defined High Performance Feed	CHO-K1、CHO-DG44、CHO-S
AltairCHO^® Feed Plus NEW	P226220	Liquid	500mL /1000mL	Chemically Defined High Performance Feed	CHO-K1、CHO-DG44、CHO-S
VegaCHO^® DPM	P106390	Dry powder	10L/50L/100L	Chemically Defined Medium	CHO-K1、CHO-DG44、CHO-S、CHOZN
VegaCHO^® Medium	P121662	Liquid	1000mL	Chemically Defined Medium	CHO-K1、CHO-DG44、CHO-S、CHOZN
VegaCHO^® Feed DPM	P120826	Dry powder	10L	Chemically Defined High Performance Feed	CHO-K1、CHO-DG44、CHO-S、CHOZN
VegaCHO^® Feed	P134305	Liquid	1000mL	Chemically Defined High Performance Feed	CHO-K1、CHO-DG44、CHO-S、CHOZN
VegaCHO^® Feed Plus DPM NEW	P220818	Dry powder	10L/50L	Chemically Defined High Performance Feed	CHO-K1、CHO-DG44、CHO-S、CHOZN
VegaCHO^® Feed Plus NEW	P223530	Liquid	500mL /1000mL	Chemically Defined High Performance Feed	CHO-K1、CHO-DG44、CHO-S、CHOZN
StarCHO^TM DPM NEW	P226718	Dry powder	10L/50L/100L	Chemically Defined Medium	CHOZN、CHO-K1、CHODG44、CHO-S
StarCHO^TM Medium NEW	P225082	Liquid	1000mL	Chemically Defined Medium	CHOZN、CHO-K1、CHODG44、CHO-S
StarCHO^TM Feed DPM NEW	P224028	Dry powder	10L	Chemically Defined High Performance Feed	CHOZN、CHO-K1、CHODG44、CHO-S
StarCHO^TM Feed NEW	P223635	Liquid	1000mL	Chemically Defined High Performance Feed	CHOZN、CHO-K1、CHODG44、CHO-S
SagiCHO^TM DPM NEW	P220618	Dry powder	10L/50L/100L	Chemically Defined Medium	CHO-K1、CHO-DG44、CHO-S
SagiCHO^TM Medium NEW	P226301	Liquid	1000mL	Chemically Defined Medium	CHO-K1、CHO-DG44、CHO-S
CDFS36 DPM	C672069	Dry powder	1L//10L/50L	Highly Concentrated Feed	CHO-K1、CHO-DG44、CHO-S、CHOZN
CDFS36	C217836	Liquid	500mL/1000mL	Highly Concentrated Feed	CHO-K1、CHO-DG44、CHO-S、CHOZN
OPM-CHO CD07 DPM	P091307-010	Dry powder	10L	Chemically Defined Medium	CHO-K1、CHO-DG44、CHO-S
OPM-CHO CD07 DPM	P091307-050	Dry powder	50L	Chemically Defined Medium	CHO-K1、CHO-DG44、CHO-S
OPM-CHO CD07 DPM	P091307-100	Dry powder	100L	Chemically Defined Medium	CHO-K1、CHO-DG44、CHO-S
OPM-CHO CD07 Medium	P081307-001	Liquid	1000mL	Chemically Defined Medium	CHO-K1、CHO-DG44、CHO-S
OPM-CHO CD063 DPM	C483260	Dry powder	10L/50L/100L	Chemically Defined Medium	CHO-K1、CHO-DG44、CHO-S
OPM-CHO CD063 Medium	C602502	Liquid	1000mL	Chemically Defined Medium	CHO-K1、CHO-DG44、CHO-S
OPM-CHO CDP9 DPM	P091909-010	Dry powder	10L	Chemically Defined Medium	CHO-K1、CHO-DG44、CHO-S
OPM-CHO CDP9 DPM	P091909-050	Dry powder	50L	Chemically Defined Medium	CHO-K1、CHO-DG44、CHO-S
OPM-CHO CDP9 Medium	P081909-001	Liquid	1000mL	Chemically Defined Medium	CHO-K1、CHO-DG44、CHO-S
CHO CD052 DPM	C524031	Dry powder	10L/50L/100L	Chemically Defined Medium	CHO-K1、CHO-DG44、CHO-S、CHOZN
CHO CD052 Medium	C522032	Liquid	500mL/1000mL	Chemically Defined Medium	CHO-K1、CHO-DG44、CHO-S、CHOZN
OPM-CHO CDP3 DPM	P091863-010	Dry powder	10L	Chemically Defined Medium	CHO-K1、CHO-DG44、CHO-S、CHOZN
OPM-CHO CDP3 DPM	P091863-050	Dry powder	50L	Chemically Defined Medium	CHO-K1、CHO-DG44、CHO-S、CHOZN
OPM-CHO CDP3 Medium	P081863-001	Liquid	1000mL	Chemically Defined Medium	CHO-K1、CHO-DG44、CHO-S、CHOZN
OPM-CHO CDF18 DPM	F091718-001	Dry powder	1L	Chemically Defined High Performance Feed	CHO-K1、CHO-DG44、CHO-S
OPM-CHO CDF18 DPM	F091718-010	Dry powder	10L	Chemically Defined High Performance Feed	CHO-K1、CHO-DG44、CHO-S
OPM-CHO CDF18 DPM	F091718-050	Dry powder	50L	Chemically Defined High Performance Feed	CHO-K1、CHO-DG44、CHO-S
OPM-CHO CDF18	F081718-500	Liquid	500mL	Chemically Defined High Performance Feed	CHO-K1、CHO-DG44、CHO-S
CDF056	C504219	Liquid	100mL/500mL/1000mL	Chemically Defined High Performance Feed	CHO-K1、CHO-DG44、CHO-S、CHOZN
CDF056 DPM	C514135	Dry powder	10L/50L	Chemically Defined High Performance Feed	CHO-K1、CHO-DG44、CHO-S、CHOZN
OPM-CHO PFF05 DPM	F91279-010	Dry powder	10L	High Performance Protein-free feed	CHO-K1、CHO-DG44、CHO-S
OPM-CHO PFF05	F81279-001	Liquid	1000mL	High Performance Protein-free feed	CHO-K1、CHO-DG44、CHO-S
OPM-ACA	S0907001-100	Liquid	100mL	Supplement for reducing cell clumping	CHO-K1、CHO-DG44、CHO-S、CHOZN
OPM-GAL+V2	S081912-001	Liquid	1000mL	Supplement for regulating galactosylation level	CHO-K1、CHO-DG44、CHO-S、CHOZN
OPM-CHO CDF11	S2001-100	Liquid	100mL	Supplement for regulating galactosylation level	CHO-K1、CHO-DG44、CHO-S、CHOZN
OPM-CHO CDF11	S2001-500	Liquid	500mL	Supplement for regulating galactosylation level	CHO-K1、CHO-DG44、CHO-S、CHOZN
OPM-CHO CDF11	S2001-001	Liquid	1000mL	Supplement for regulating galactosylation level	CHO-K1、CHO-DG44、CHO-S、CHOZN
CDFS05 DPM	C216105	Dry powder	1L/10L/50L	Supplement for increasing sialic acid level	CHO-K1、CHO-DG44、CHO-S、CHOZN
CDFS05	R180067	Liquid	250mL	Supplement for increasing sialic acid level	CHO-K1、CHO-DG44、CHO-S、CHOZN

Name	Cat No.	Form	Volume	Type	Cell line	SDS	Description
OPM-CD TransCHO^® DPM	P93059	Dry powder	10L/50L/100L	Chemically Defined Medium for Transient Transfection	CHO-K1、CHO-DG44、CHO-S
OPM-CD TransCHO^®	P83059	Liquid	1000mL	Chemically Defined Medium for Transient Transfection	CHO-K1、CHO-DG44、CHO-S
OPM-CHO ProFeed	P81279	Liquid	1000mL	Chemically Defined High Performance Feed for Transient Transfection	CHO-K1、CHO-DG44、CHO-S
OPM-CHO CD08 DPM	P091308-010	Dry powder	10L	Chemically Defined Medium for Transfection	CHO-K1、CHO-DG44、CHO-S
OPM-CHO CD08 DPM	P091308-050	Dry powder	50L	Chemically Defined Medium for Transfection	CHO-K1、CHO-DG44、CHO-S
OPM-CHO CD08 Medium	P081308-001	Liquid	1000mL	Chemically Defined Medium for Transfection	CHO-K1、CHO-DG44、CHO-S
OPM-CHO PFF06 DPM	1275F05-010	Dry powder	10L	High Performance Protein-free feed for Transient Transfection	CHO-K1、CHO-DG44、CHO-S
OPM-CHO PFF06	1265F05-001	Liquid	1000mL	High Performance Protein-free feed for Transient Transfection	CHO-K1、CHO-DG44、CHO-S

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*We only support downloading the CoA documents of OPM-CHO series on this page

OPM products have been cited as follows

Developing a medium combination to attain similar glycosylation profile to originator by DoE and cluster analysis method
Sci Rep. 2021 Mar 29;11(1):7103.
Establishing functional lentiviral vector production in a stirred bioreactor for CAR-T cell therapy
Bioengineered. 2021 Dec;12(1):2095-2105.
Establishing 293T suspension cultrue for lentiviral vector production in a stirred bioreactor
Authorea. 2020 November 10.

Case Study

AltairCHO™ (Growth factor independent cell lines)

VegaCHO™ (Growth factor dependent cell lines)

OPM-CHO – Commercial CHO media platform

The OPM-CHO platform is designed to achieve optimal cell culture performance, in terms of high density cell growth, high titer and desired quality. OPM-CHO media provide cell culture solutions for transient transfection and stable cell lines, both in small scale and large scale biotherapeutic manufacturing.

AltairCHO™ and VegaCHO™ are the new generation CHO media of high-performing chemically defined media, without any animal-derived component. These cell culture media efficiently support high levels of expression of recombinant proteins and therapeutic antibodies in high-density suspension culture of all CHO cells, including wild-type and genetically engineered cell lines such as CHO-K1, CHO DG44 and CHO-S, CHO-M, etc.

FAQ